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<p style="display: none;">Article continues below</p><p style="display: none;">Article continues below</p><p style="display: none;">Article continues below</p><script type="application/json" data-placement="fcplayer-semantic">{"type":"fcplayer-semantic","data":{"embedCode":"//cdn.fcp.codes/embed-code-template/embed-code-template.js#SEMANTIC_5704afb8-c10b-4ba5-9cb4-d7fb6098ef90"}}</script><ul><li>Newcastle United host Manchester City</li><li>Targett looked set for first game of season</li><li>Ruled out due to rarely-seen medical condition</li></ul><p></p><table><tbody><tr><td><a href="https://www.whatsapp.com/channel/0029Va2ivxLJJhzdzbJdwo0n"><strong>Follow GOAL on WhatsApp!</strong></a> 🟢📱</td></tr></tbody></table>

Explained: The rarely-seen medical condition that has ruled Newcastle star Matt Targett out of blockbuster clash with Man City

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<p>The former Aston Villa man has not played for Newcastle this season and had an injury-hit campaign in 2023/24. Now, more bad luck has befallen him ahead of Saturday's Premier League clash with Pep Guardiola's men. Toon manager Eddie Howe confirmed the 29-year-old would not be available and here's why.</p>

WHAT HAPPENED?

<p>On Friday, Howe told reporters that Targett's eczema had been playing up in recent weeks. </p><p>"Matt had a flare-up of eczema, so he's been nursing that the last couple of weeks. It's been quite a bad episode for him. We're hoping to get him back to training, but he won't play this weekend," he said in his pre-match press conference.</p>

THE EXPLANATION

<p>Targett joined Newcastle on loan from Villa in the 2021/22 season before signing a four-year deal that summer for £15 million ($20m). Despite a bright start, he has been struck down by long-term hamstring and Achilles problems since then and missed 35 games last term. </p>

DID YOU KNOW?

<p>After Newcastle host City on Saturday, the Magpies take on AFC Wimbledon in round three of the Carabao Cup on October 1 before returning to Premier League action away to lowly Everton four days later. Targett will hope to be available for his side soon.</p>

WHAT NEXT?

Explained: The rarely-seen medical condition that has ruled Newcastle star Matt Targett out of blockbuster clash with Man City | Goal.com

Newcastle United left-back Matt Targett has been ruled out of his side&apos;s crunch clash with Manchester City due to a rarely-seen medical condition.